Adrenal medullary chromaffin cells in vitro

BG Livett - Physiological reviews, 1984 - journals.physiology.org
BG Livett
Physiological reviews, 1984journals.physiology.org
The application of cell culture techniques to the isolation and long-term maintenance of
adrenal chromaffin cells in vitro has renewed interest in these neural crest derivatives. Such
cultures have been particularly useful in establishing the molecular and ionic bases of
hormone secretion (163) and in revealing possible mechanisms that may control phenotypic
and chemical plasticity during development of the autonomic nervous system (62,256,257,
289). Comparisons between these primary cell cultures and related tumor cell lines (eg; the …
The application of cell culture techniques to the isolation and long-term maintenance of adrenal chromaffin cells in vitro has renewed interest in these neural crest derivatives. Such cultures have been particularly useful in establishing the molecular and ionic bases of hormone secretion (163) and in revealing possible mechanisms that may control phenotypic and chemical plasticity during development of the autonomic nervous system (62,256,257, 289). Comparisons between these primary cell cultures and related tumor cell lines (eg; the transplantable rat PC12 pheochromocytoma cell line; 94, 260, 261) have been particularly valuable in revealing processes that are common to chromaffin cells and pheochromocytoma cells, as distinct from
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