Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease
M Corral-Debrinski, JM Shoffner, MT Lott… - Mutation Research …, 1992 - Elsevier
The role of somatic mitochondrial DNA (mtDNA) damage in human aging and progressive
diseases of oxidative phosphorylation (OXPHOS) was examined by quantitating the
accumulation of mtDNA deletions in normal hearts and hearts with coronary atherosclerotic
disease. In normal hearts, mtDNA deletions appeared after 40 and subsequently
accumulated with age. The common 4977 nucleotide pair (np) deletion (mtDNA 4977)
reached a maximum of 0.007%, with the mtDNA 7436 and mtDNA 10,422 deletions …
diseases of oxidative phosphorylation (OXPHOS) was examined by quantitating the
accumulation of mtDNA deletions in normal hearts and hearts with coronary atherosclerotic
disease. In normal hearts, mtDNA deletions appeared after 40 and subsequently
accumulated with age. The common 4977 nucleotide pair (np) deletion (mtDNA 4977)
reached a maximum of 0.007%, with the mtDNA 7436 and mtDNA 10,422 deletions …