Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes
JE Horton, LG Raisz, HA Simmons, JJ Oppenheim… - Science, 1972 - science.org
JE Horton, LG Raisz, HA Simmons, JJ Oppenheim, SE Mergenhagen
Science, 1972•science.orgA new soluble mediator was found in supernatant fluid from cultures of human peripheral
blood leukocytes that were stimulated by phytohemagglutinin, or by antigenic material
present in human dental plaque deposits. This soluble factor produced bone resorption in
organ cultures of fetal rat bones as measured by increased release of calcium-45, and also
increased the number of active osteoclasts.
blood leukocytes that were stimulated by phytohemagglutinin, or by antigenic material
present in human dental plaque deposits. This soluble factor produced bone resorption in
organ cultures of fetal rat bones as measured by increased release of calcium-45, and also
increased the number of active osteoclasts.
A new soluble mediator was found in supernatant fluid from cultures of human peripheral blood leukocytes that were stimulated by phytohemagglutinin, or by antigenic material present in human dental plaque deposits. This soluble factor produced bone resorption in organ cultures of fetal rat bones as measured by increased release of calcium-45, and also increased the number of active osteoclasts.
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