Immunodominant minor histocompatibility antigens: the major ones
C Perreault, DC Roy, C Fortin - Immunology today, 1998 - cell.com
C Perreault, DC Roy, C Fortin
Immunology today, 1998•cell.comMinor histocompatibility antigens (MiHAs) are extremely numerous—possibly up to 720 in
mice—and have been regarded as animmunogenetic nightmare'in transplantation. Here,
Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most
anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant MiHAs,
rather than polyclonal. This concept has important implications in transplantation and cancer
immunotherapy.
mice—and have been regarded as animmunogenetic nightmare'in transplantation. Here,
Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most
anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant MiHAs,
rather than polyclonal. This concept has important implications in transplantation and cancer
immunotherapy.
Abstract
Minor histocompatibility antigens (MiHAs) are extremely numerous—possibly up to 720 in mice—and have been regarded as an `immunogenetic nightmare' in transplantation. Here, Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant MiHAs, rather than polyclonal. This concept has important implications in transplantation and cancer immunotherapy.
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