[HTML][HTML] An AP-1 Binding Sequence Is Essential for Regulation of the Human α2 (I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-β (∗)
Previous studies have shown that transforming growth factor-β (TGF-β) and tumor necrosis
factor-α (TNF-α) modulate type I collagen gene expression in fibroblasts. To fine-map the
corresponding response elements in the human α2 (I) collagen (COL1A2) promoter, we
have generated a series of 5′ deletion promoter/chloramphenicol acetyltransferase (CAT)
reporter gene constructs. Transient cell transfection assays using human dermal fibroblasts
and stable transfection experiments using NIH 3T3 fibroblasts identified the region located …
factor-α (TNF-α) modulate type I collagen gene expression in fibroblasts. To fine-map the
corresponding response elements in the human α2 (I) collagen (COL1A2) promoter, we
have generated a series of 5′ deletion promoter/chloramphenicol acetyltransferase (CAT)
reporter gene constructs. Transient cell transfection assays using human dermal fibroblasts
and stable transfection experiments using NIH 3T3 fibroblasts identified the region located …