Long-term sun exposure alters the collagen of thepapillary dermis: Comparison of sun-protected and photoaged skin by Northern analysis, immunohistochemical …
EF Bernstein, YQ Chen, JB Kopp, L Fisher… - Journal of the American …, 1996 - Elsevier
Background: Long-term solar irradiation produces both morphologic and functional changes
in affected skin. Because collagen is the major structural component of skin, any alteration in
its production or degradation could have profound effects on cutaneous functional integrity.
Objective: Our purpose was to investigate alterations in the production and morphology
ofcollagen fibers brought about by long-term sun exposure. Methods: We compared
collagen and collagenase gene expression and collagen immunohistochemical staining …
in affected skin. Because collagen is the major structural component of skin, any alteration in
its production or degradation could have profound effects on cutaneous functional integrity.
Objective: Our purpose was to investigate alterations in the production and morphology
ofcollagen fibers brought about by long-term sun exposure. Methods: We compared
collagen and collagenase gene expression and collagen immunohistochemical staining …