Caspases: killer proteases
DW Nicholson, NA Thornberry - Trends in biochemical sciences, 1997 - cell.com
DW Nicholson, NA Thornberry
Trends in biochemical sciences, 1997•cell.comCaspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic
cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key
and central role that these enzymes play in a biochemical cell-suicide pathway has been
conserved throughout the evolution of multicellular eukaryotes.
cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key
and central role that these enzymes play in a biochemical cell-suicide pathway has been
conserved throughout the evolution of multicellular eukaryotes.
Abstract
Caspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key and central role that these enzymes play in a biochemical cell-suicide pathway has been conserved throughout the evolution of multicellular eukaryotes.
cell.com