[HTML][HTML] Regulation of Inosine-5′-monophosphate Dehydrogenase Type II Gene Expression in Human T Cells: ROLE FOR A NOVEL 5′ PALINDROMIC OCTAMER …
AG Zimmermann, KL Wright, JPY Ting… - Journal of Biological …, 1997 - ASBMB
Expression of the gene encoding human inosine-5′-monophosphate dehydrogenase
(IMPDH) type II, an enzyme catalyzing the rate-limiting step in the generation of guanine
nucleotides, is increased more than 10-fold in activated peripheral blood T lymphocytes and
is required for T cell activation. We have examined the 5′-regulatory sequences that are
important for the transcriptional regulation of this gene in T cells. DNase I mapping of
genomic DNA identified a hypersensitive element near the transcription initiation site. Fine …
(IMPDH) type II, an enzyme catalyzing the rate-limiting step in the generation of guanine
nucleotides, is increased more than 10-fold in activated peripheral blood T lymphocytes and
is required for T cell activation. We have examined the 5′-regulatory sequences that are
important for the transcriptional regulation of this gene in T cells. DNase I mapping of
genomic DNA identified a hypersensitive element near the transcription initiation site. Fine …