[HTML][HTML] Characterization of the Human Inosine-5′-monophosphate Dehydrogenase Type II Gene (∗)
AG Zimmermann, J Spychala, BS Mitchell - Journal of Biological Chemistry, 1995 - ASBMB
Inosine-5′-monophosphate dehydrogenase (IMPDH) activity and mRNA levels are
induced up to 15-fold upon mitogenic or antigenic stimulation of human peripheral blood T
lymphocytes. This increase in IMPDH activity is required for cellular proliferation and has
been associated with malignant transformation. We have cloned the human IMPDH type II
gene and show that it contains 14 exons and is approximately 5.8 kilobases in length. Exons
vary in size from 49 to 207 base pairs and introns from 73 to 1065 base pairs. The …
induced up to 15-fold upon mitogenic or antigenic stimulation of human peripheral blood T
lymphocytes. This increase in IMPDH activity is required for cellular proliferation and has
been associated with malignant transformation. We have cloned the human IMPDH type II
gene and show that it contains 14 exons and is approximately 5.8 kilobases in length. Exons
vary in size from 49 to 207 base pairs and introns from 73 to 1065 base pairs. The …