[HTML][HTML] Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene
T Ohga, T Uchiumi, Y Makino, K Koike, M Wada… - Journal of Biological …, 1998 - ASBMB
The human multidrug resistance 1 (MDR1) gene encoding P-glycoprotein is often
overexpressed in various human tumors after chemotherapy. During treatment with various
chemotherapeutic agents, the MDR1 gene is activated at the transcriptional level and/or
amplified, resulting in overexpression. Our previous studies demonstrated that an inverted
CCAAT box (Y-box) might be a critical cis-regulatory element regulating UV or drug-induced
MDR1 gene expression. We have now established various cell lines from human head and …
overexpressed in various human tumors after chemotherapy. During treatment with various
chemotherapeutic agents, the MDR1 gene is activated at the transcriptional level and/or
amplified, resulting in overexpression. Our previous studies demonstrated that an inverted
CCAAT box (Y-box) might be a critical cis-regulatory element regulating UV or drug-induced
MDR1 gene expression. We have now established various cell lines from human head and …