[HTML][HTML] Identification of a Thrombin Response Element in the Human Platelet-derived Growth Factor B-chain (c-sis) Promoter (∗)

EM Scarpati, PE DiCorleto - Journal of Biological Chemistry, 1996 - ASBMB
Thrombin is a coagulation system protease that also serves as a potent stimulator of gene
expression in several cell types, including endothelial cells (EC). We and others have
previously demonstrated that the transcription of platelet-derived growth factor (PDGF) B-
chain (c-sis) by EC is stimulated severalfold by thrombin. Here we examine the molecular
mechanism of this regulatory process using bovine aortic EC transiently transfected with a
vector containing the chloramphenicol acetyltransferase (CAT) gene under the control of a …