[HTML][HTML] Cloning of a Putative Ligand for the T1/ST2 Receptor (∗)
MA Gayle, JL Slack, TP Bonnert, BR Renshaw… - Journal of Biological …, 1996 - ASBMB
T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite
this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of
the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell
surface protein to which it binds. This protein is unable to initiate signal transduction by the
T1/ST2 receptor in several in vitro assays.
this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of
the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell
surface protein to which it binds. This protein is unable to initiate signal transduction by the
T1/ST2 receptor in several in vitro assays.