Expression of vascular endothelial growth factor receptors in human prostate cancer
FA Ferrer, LJ Miller, R Lindquist, P Kowalczyk… - Urology, 1999 - Elsevier
Objectives. We recently reported the expression and cytokine regulation of vascular
endothelial growth factor (VEGF) in human prostate cancer (PCa). VEGF exerts its
angiogenic and pro-tumorigenic properties by way of two high affinity receptors, fms-like
tyrosine kinase 1 (FLT-1) and fetal liver kinase 1 (FLK-1). We hypothesized that these
receptors are expressed and control VEGF functions in the PCa microenvironment. Herein,
we evaluate the expression of these receptors in ex vivo PCa tissue, benign prostatic …
endothelial growth factor (VEGF) in human prostate cancer (PCa). VEGF exerts its
angiogenic and pro-tumorigenic properties by way of two high affinity receptors, fms-like
tyrosine kinase 1 (FLT-1) and fetal liver kinase 1 (FLK-1). We hypothesized that these
receptors are expressed and control VEGF functions in the PCa microenvironment. Herein,
we evaluate the expression of these receptors in ex vivo PCa tissue, benign prostatic …