[HTML][HTML] Identification of the residues in the extracellular region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR …
D Lu, P Kussie, B Pytowski, K Persaud, P Bohlen… - Journal of Biological …, 2000 - ASBMB
The kinase domain receptor (KDR) of vascular endothelial growth factor (VEGF) is the main
human receptor responsible for the angiogenic activity of VEGF. The extracellular region of
KDR is comprised of seven immunoglobulin-like domains, of which the first three have been
shown to be required for ligand binding. We have previously described antibodies directed
against the extracellular region of KDR, including MAB383 and MAB664, which were shown
to block the binding of VEGF to the receptor and to inhibit both VEGF-induced mitogenesis of …
human receptor responsible for the angiogenic activity of VEGF. The extracellular region of
KDR is comprised of seven immunoglobulin-like domains, of which the first three have been
shown to be required for ligand binding. We have previously described antibodies directed
against the extracellular region of KDR, including MAB383 and MAB664, which were shown
to block the binding of VEGF to the receptor and to inhibit both VEGF-induced mitogenesis of …