Leptin, secreted by adipocytes, regulates satiety and energy expenditure. Several forms of
leptin receptors produced by alternative mRNA splicing are found in many tissues, including
the hypothalamus, liver, lung, kidney, hematopoietic cells, and gonads, suggesting that
leptin exerts effects in these tissues. In accordance with the distribution of leptin receptors,
there is accumulating evidence that leptin plays various roles in reproduction,
hematopoiesis, and the immune systems in addition to the regulation of food intake and …