[HTML][HTML] Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without …
PA Staubs, JG Nelson, DR Reichart… - Journal of Biological …, 1998 - ASBMB
Phosphatidylinositol 3-kinase (PI3K) activation is necessary for insulin-responsive glucose
transporter (GLUT4) translocation and glucose transport. Insulin and platelet-derived growth
factor (PDGF) stimulate PI3K activity in 3T3-L1 adipocytes, but only insulin is capable of
stimulating GLUT4 translocation and glucose transport. We found that PDGF causes
serine/threonine phosphorylation of insulin receptor substrate 1 (IRS-1) in 3T3-L1 cells,
measured by altered mobility on SDS-polyacrylamide gel, and this leads to a decrease in …
transporter (GLUT4) translocation and glucose transport. Insulin and platelet-derived growth
factor (PDGF) stimulate PI3K activity in 3T3-L1 adipocytes, but only insulin is capable of
stimulating GLUT4 translocation and glucose transport. We found that PDGF causes
serine/threonine phosphorylation of insulin receptor substrate 1 (IRS-1) in 3T3-L1 cells,
measured by altered mobility on SDS-polyacrylamide gel, and this leads to a decrease in …