Angiotensin II stimulates the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells.
AJ Lokuta, C Cooper, ST Gaa, HE Wang… - Journal of Biological …, 1994 - ASBMB
The octapeptide angiotensin II (Ang-II) induces both acute functional changes and longer
lasting molecular changes in cultured mammalian heart myocytes, yet the underlying
molecular mechanisms are poorly understood. In this study, Ang-II was found to stimulate a
sustained release (> 30 min) of arachidonic acid (ARA) from cultured neonatal rat cardiac
myocytes, with a half-maximal response observed at 0.1 nM. Mass spectroscopy analysis
showed that Ang-II stimulated a specific release equivalent to 104 fmol of ARA/micrograms …
lasting molecular changes in cultured mammalian heart myocytes, yet the underlying
molecular mechanisms are poorly understood. In this study, Ang-II was found to stimulate a
sustained release (> 30 min) of arachidonic acid (ARA) from cultured neonatal rat cardiac
myocytes, with a half-maximal response observed at 0.1 nM. Mass spectroscopy analysis
showed that Ang-II stimulated a specific release equivalent to 104 fmol of ARA/micrograms …