Nitric oxide synthases: gene structure and regulation
Y Wang, PA Marsden - Advances in pharmacology, 1995 - Elsevier
Publisher Summary The nitric oxide (NO) synthases (NOSs) are a family of complex
enzymes that catalyze the five-electron oxidation of L-arginine to form NO and L-citrulline.
They are best characterized as cytochrome P-450-like hemeproteins that depend on
molecular oxygen, nicotinamide adenine dinucleotide-phosphate (NADPH), flavins, and
tetrahydrobiopterin. The NOSs constitute a family with at least three distinct isoforms. In
order of their molecular characterization, these include the neuronal (nNOS, NOS1) …
enzymes that catalyze the five-electron oxidation of L-arginine to form NO and L-citrulline.
They are best characterized as cytochrome P-450-like hemeproteins that depend on
molecular oxygen, nicotinamide adenine dinucleotide-phosphate (NADPH), flavins, and
tetrahydrobiopterin. The NOSs constitute a family with at least three distinct isoforms. In
order of their molecular characterization, these include the neuronal (nNOS, NOS1) …