[HTML][HTML] Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase

J Kotera, K Fujishige, H Akatsuka, Y Imai… - Journal of Biological …, 1998 - ASBMB
After our recent findings that the amino-terminal portion of rat cGMP-binding, cGMP-specific
phosphodiesterase (cGB-PDE) differs from those of bovine and human cGB-PDEs, we found
two forms of canine cGB-PDE cDNAs (CFPDE5A1 and CFPDE5A2) in canine lung. Each
contained a distinct amino-terminal sequence, CFPDE5A1, possessing an amino-terminal
portion with sequence similar to those of bovine and human, and CFPDE5A2, having one
similar to that of rat. Other portions coding for the cGMP binding domains and the catalytic …