Genetic evidence for the neuronal nitric oxide synthase gene (NOS1) as a susceptibility locus for infantile pyloric stenosis.

E Chung, D Curtis, G Chen, PA Marsden… - American journal of …, 1996 - ncbi.nlm.nih.gov
E Chung, D Curtis, G Chen, PA Marsden, R Twells, W Xu, M Gardiner
American journal of human genetics, 1996ncbi.nlm.nih.gov
The etiological role of the gene for neuronal nitric oxide synthase (NOS1) in infantile pyloric
stenosis (PS) was investigated by analysis of two intragenic polymorphisms (NOS1a and
NOS1b) in 27 families. There was significant overall transmission disequilibrium between
PS and NOS1a (P=. 006). Consideration of each allele independently revealed a highly
significant tendency for allele 7 (210 bp) to be preferentially transmitted to the affected
offspring (P=. 0006). These observations suggest that NOS1 is a susceptibility locus for PS.
Abstract
The etiological role of the gene for neuronal nitric oxide synthase (NOS1) in infantile pyloric stenosis (PS) was investigated by analysis of two intragenic polymorphisms (NOS1a and NOS1b) in 27 families. There was significant overall transmission disequilibrium between PS and NOS1a (P=. 006). Consideration of each allele independently revealed a highly significant tendency for allele 7 (210 bp) to be preferentially transmitted to the affected offspring (P=. 0006). These observations suggest that NOS1 is a susceptibility locus for PS.
ncbi.nlm.nih.gov