[HTML][HTML] Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor κB-dependent mechanism
CM McKee, CJ Lowenstein, MR Horton, J Wu… - Journal of Biological …, 1997 - ASBMB
Activated macrophages play a critical role in controlling chronic tissue inflammation through
the release of a variety of mediators including cytokines, chemokines, growth factors, active
lipids, reactive oxygen, and nitrogen species. The mechanisms that regulate macrophage
activation in chronic inflammation are poorly understood. A hallmark of chronic inflammation
is the turnover of extracellular matrix components, and recent work has suggested that
interactions with the extracellular matrix can exert important influences on macrophage …
the release of a variety of mediators including cytokines, chemokines, growth factors, active
lipids, reactive oxygen, and nitrogen species. The mechanisms that regulate macrophage
activation in chronic inflammation are poorly understood. A hallmark of chronic inflammation
is the turnover of extracellular matrix components, and recent work has suggested that
interactions with the extracellular matrix can exert important influences on macrophage …