Silent cerebral infarcts in sickle cell anemia: a risk factor analysis

TR Kinney, LA Sleeper, WC Wang, RA Zimmerman… - …, 1999 - publications.aap.org
Background. Silent infarcts have been reported in 17% of young patients with sickle cell
disease and are associated with impaired performance on standardized psychometric tests.
Risk factors for the development of these lesions have not been identified. Methods.
Investigators in the Cooperative Study of Sickle Cell Disease performed a brain magnetic
resonance imaging scan on sickle cell anemia patients age 5.9 years and older who had
been followed according to the protocols of the Cooperative Study since birth. Individuals …