Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

E Lander, L Kruglyak - Nature genetics, 1995 - nature.com
E Lander, L Kruglyak
Nature genetics, 1995nature.com
Genetic studies are under way for many complex traits, spurred by the recent feasibility of
whole genome scans. Clear guidelines for the interpretation of linkage results are needed to
avoid a flood of false positive claims. At the same time, an overly cautious approach runs the
risk of causing true hints of linkage to be missed. We address this problem by proposing
specific standards designed to maintain rigor while also promoting communication.
Abstract
Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication.
nature.com