[HTML][HTML] Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4
I Shiojima, I Komuro, T Oka, Y Hiroi, T Mizuno… - Journal of Biological …, 1999 - ASBMB
Although the cardiac homeobox geneCsx/Nkx-2.5 is essential for normal heart development,
little is known about its regulatory mechanisms. In a search for the downstream target genes
of Csx/Nkx-2.5, we found that the atrial natriuretic peptide (ANP) gene promoter was strongly
transactivated by Csx/Nkx-2.5. Deletion and mutational analyses of the ANP promoter
revealed that the Csx/Nkx-2.5-binding element (NKE2) located at− 240 was required for high
level transactivation by Csx/Nkx-2.5. We also found that Csx/Nkx-2.5 and GATA-4 displayed …
little is known about its regulatory mechanisms. In a search for the downstream target genes
of Csx/Nkx-2.5, we found that the atrial natriuretic peptide (ANP) gene promoter was strongly
transactivated by Csx/Nkx-2.5. Deletion and mutational analyses of the ANP promoter
revealed that the Csx/Nkx-2.5-binding element (NKE2) located at− 240 was required for high
level transactivation by Csx/Nkx-2.5. We also found that Csx/Nkx-2.5 and GATA-4 displayed …