Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
D Hanahan - Nature, 1985 - nature.com
Nature, 1985•nature.com
Following the transfer into fertilized mouse eggs of recombinant genes composed of the
upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen
of simian virus 40, large-T antigen is detected exclusively in the β-Cells of the endocrine
pancreas of transgenic mice. The α-and δ-cells normally found in the islets of Langerhans
are rare and disordered. Well-vascularized β-cell tumours arise in mice harbouring and
inheriting these hybrid oncogenes.
upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen
of simian virus 40, large-T antigen is detected exclusively in the β-Cells of the endocrine
pancreas of transgenic mice. The α-and δ-cells normally found in the islets of Langerhans
are rare and disordered. Well-vascularized β-cell tumours arise in mice harbouring and
inheriting these hybrid oncogenes.
Abstract
Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the β-Cells of the endocrine pancreas of transgenic mice. The α- and δ-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized β-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes.
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