[HTML][HTML] Insulin receptor substrate-2 is not necessary for insulin-and exercise-stimulated glucose transport in skeletal muscle
Y Higaki, JFP Wojtaszewski, MF Hirshman… - Journal of Biological …, 1999 - ASBMB
Insulin receptor substrate-2-deficient (IRS2−/−) mice develop type 2 diabetes. The purpose
of this study was to determine whether there is a defect in basal, insulin-, and exercise-
stimulated glucose transport in the skeletal muscle of these animals. IRS2−/− and wild-type
(WT) mice (male, 8–10 weeks) exercised on a treadmill for 1 h or remained sedentary. 2-
Deoxyglucose (2DG) uptake was measured in isolated soleus muscles incubated in vitro in
the presence or absence of insulin. Resting blood glucose concentration in IRS2−/− mice …
of this study was to determine whether there is a defect in basal, insulin-, and exercise-
stimulated glucose transport in the skeletal muscle of these animals. IRS2−/− and wild-type
(WT) mice (male, 8–10 weeks) exercised on a treadmill for 1 h or remained sedentary. 2-
Deoxyglucose (2DG) uptake was measured in isolated soleus muscles incubated in vitro in
the presence or absence of insulin. Resting blood glucose concentration in IRS2−/− mice …