Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis
K Jujo, H Renz, J Abe, EW Gelfand… - Journal of allergy and …, 1992 - Elsevier
The mechanism (s) responsible for increased IgE synthesis in atopic dermatitis (AD) are
unknown, but they may be related to either decreased interferon gamma (IFN-γ) and/or
increased interleukin (IL)-4 production. In this study we examined peripheral blood
mononuclear cells (PBMCs) from 21 patients with AD, six patients with psoriasis, and 22
nonatopic healthy controls for IFN-γ and IL-4 production after stimulation with concanavalin
A (Con A). The Con A-induced proliferative response of AD PBMCs was similar to the …
unknown, but they may be related to either decreased interferon gamma (IFN-γ) and/or
increased interleukin (IL)-4 production. In this study we examined peripheral blood
mononuclear cells (PBMCs) from 21 patients with AD, six patients with psoriasis, and 22
nonatopic healthy controls for IFN-γ and IL-4 production after stimulation with concanavalin
A (Con A). The Con A-induced proliferative response of AD PBMCs was similar to the …