[HTML][HTML] Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
U Laufs, V La Fata, JK Liao - Journal of Biological Chemistry, 1997 - ASBMB
Hypoxia induces vasoconstriction, in part, by down-regulating endothelial cell nitric oxide
synthase (ecNOS) expression. Previous studies indicate that 3-hydroxy-3-methylglutaryl-
coenzyme A (HMG CoA) reductase inhibitors improve endothelium-dependent relaxation by
increasing ecNOS activity. To determine whether HMG CoA reductase inhibitors can prevent
hypoxia-mediated down-regulation of ecNOS function and expression, human endothelial
cells were exposed to hypoxia (3% O 2) in the presence of HMG CoA reductase inhibitors …
synthase (ecNOS) expression. Previous studies indicate that 3-hydroxy-3-methylglutaryl-
coenzyme A (HMG CoA) reductase inhibitors improve endothelium-dependent relaxation by
increasing ecNOS activity. To determine whether HMG CoA reductase inhibitors can prevent
hypoxia-mediated down-regulation of ecNOS function and expression, human endothelial
cells were exposed to hypoxia (3% O 2) in the presence of HMG CoA reductase inhibitors …