Palmitoylation is unique among lipid modifications in that it is reversible. In recent years,
dynamic palmitoylation of G protein α subunits and of their cognate receptors has attracted
considerable attention. However, very little is known concerning the acylation/deacylation
cycle of the proteins in relation to their activity status. In particular, the relative contribution of
the activation and desensitization of the signaling unit to the regulation of the receptors and
G proteins palmitoylation state is unknown. To address this issue, we took advantage of the …