Role of G Protein–Coupled Receptor Kinase 2 and Arrestins in β-Adrenergic Receptor Internalization
F Mayor Jr, P Penela, A Ruiz-Gómez - Trends in cardiovascular medicine, 1998 - Elsevier
G protein–coupled receptors (GPCRs) mediate the action of messengers that are key
modulators of the function, growth, and differentiation of cardiac and vascular cells. A
general feature of GPCRs is the existence of complex regulatory mechanisms that modulate
receptor responsiveness and underlie important physiologic phenomena such as signal
integration and desensitization. The molecular mechanisms of desensitization have been
investigated with the β2-adrenergic receptor (β2AR) used as the main model system. Rapid …
modulators of the function, growth, and differentiation of cardiac and vascular cells. A
general feature of GPCRs is the existence of complex regulatory mechanisms that modulate
receptor responsiveness and underlie important physiologic phenomena such as signal
integration and desensitization. The molecular mechanisms of desensitization have been
investigated with the β2-adrenergic receptor (β2AR) used as the main model system. Rapid …