Bronchodilator subsensitivity after chronic dosing with eformoterol in patients with asthma
DM Newnham, DG McDevitt, BJ Lipworth - The American journal of …, 1994 - Elsevier
Abstract purpose: The aim of the present study was to evaluate in vivo and in vitro β 2-
adrenoceptor responsiveness after chronic inhaled therapy with the long-acting β 2-agonist
eformoterol or placebo, given twice daily, in patients with mild to moderate asthma. patients
and methods: Seven asthmatic patients, age 34±5 years were evaluated. Mean forced
expiratory volume in 1 second (FEV 1)(% predicted) at entry was 58±5%. After at least 2
weeks run-in without β 2-agonist therapy, patients were randomized to receive regular …
adrenoceptor responsiveness after chronic inhaled therapy with the long-acting β 2-agonist
eformoterol or placebo, given twice daily, in patients with mild to moderate asthma. patients
and methods: Seven asthmatic patients, age 34±5 years were evaluated. Mean forced
expiratory volume in 1 second (FEV 1)(% predicted) at entry was 58±5%. After at least 2
weeks run-in without β 2-agonist therapy, patients were randomized to receive regular …