A new vasopressin analogue and fibrinolysis
AMA Gader, J Da Costa, JD Cash - The Lancet, 1973 - Elsevier
AMA Gader, J Da Costa, JD Cash
The Lancet, 1973•ElsevierIn five healthy men an intravenous dose of 10 μg. of 1-desamino-8-D-arginine vasopressin
(DDAVP) stimulated a rapid systemic release of plasma-plasminogen-activator. Unlike the
responses recorded with lysine vasopressin and arginine vasopressin, the response to
DDAVP was protracted and devoid of side-effects. The magnitude of the DDAVP-induced
release of plasminogen activator was similar to that associated with moderate exercise and
intravenous adrenaline.
(DDAVP) stimulated a rapid systemic release of plasma-plasminogen-activator. Unlike the
responses recorded with lysine vasopressin and arginine vasopressin, the response to
DDAVP was protracted and devoid of side-effects. The magnitude of the DDAVP-induced
release of plasminogen activator was similar to that associated with moderate exercise and
intravenous adrenaline.
Abstract
In five healthy men an intravenous dose of 10 μg. of 1-desamino-8-D-arginine vasopressin (D.D.A.V.P.) stimulated a rapid systemic release of plasma-plasminogen-activator. Unlike the responses recorded with lysine vasopressin and arginine vasopressin, the response to D.D.A.V.P. was protracted and devoid of side-effects. The magnitude of the D.D.A.V.P.-induced release of plasminogen activator was similar to that associated with moderate exercise and intravenous adrenaline.
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