Molecular mechanisms of insulin action in normal and insulin-resistant states
Y Le Marchand-Brustel - Experimental and clinical …, 1999 - thieme-connect.com
Y Le Marchand-Brustel
Experimental and clinical endocrinology & diabetes, 1999•thieme-connect.comInsulin resistance is central to the pathophysiology of type 2 diabetes. It has been known for
some time that down-regulation and reduced kinase activity of the insulin receptor play a
role in insulin resistance; however, it has recently emerged that defects in the intracellular
responses to insulin are also very important.
some time that down-regulation and reduced kinase activity of the insulin receptor play a
role in insulin resistance; however, it has recently emerged that defects in the intracellular
responses to insulin are also very important.
Summary
Insulin resistance is central to the pathophysiology of type 2 diabetes. It has been known for some time that down-regulation and reduced kinase activity of the insulin receptor play a role in insulin resistance; however, it has recently emerged that defects in the intracellular responses to insulin are also very important.
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