Evidence that long-term cardiac allograft survival induced by anti-CD4 monoclonal antibody does not require depletion of CD4+ T cells

CR DARBY, PJ MORRIS, KJ WOOD - Transplantation, 1992 - journals.lww.com
CR DARBY, PJ MORRIS, KJ WOOD
Transplantation, 1992journals.lww.com
Monoclonal antibodies that deplete cells carrying their target antigen are being used
increasingly for immuno-suppression in clinical and experimental transplantation. We have
characterized a panel of rat antimouse CD4 monoclonal antibodies with the aim of
establishing, in a vascularized organ transplant model, whether prolonged graft survival can
be induced without recipient T cell depletion.
Abstract
Monoclonal antibodies that deplete cells carrying their target antigen are being used increasingly for immuno-suppression in clinical and experimental transplantation. We have characterized a panel of rat antimouse CD4 monoclonal antibodies with the aim of establishing, in a vascularized organ transplant model, whether prolonged graft survival can be induced without recipient T cell depletion.
Lippincott Williams & Wilkins