Inhibitory effect of interleukin-4 on osteoclast-like cell formation in mouse bone marrow culture
K Kasono, K Sato, Y Sato, T Tsushima, K Shizume… - Bone and mineral, 1993 - Elsevier
Summary Recently, interleukin 4 (IL-4) was reported to inhibit bone resorption in mouse long
bone culture. To test the effect of IL-4 on the formation of osteoclast-like cells, we used a
mouse bone marrow culture system that formed mononuclear and multinucleated cells with
osteoclast characteristics. Recombinant mouse IL-4 dose-dependently inhibited the
formation of tartrate-resistant acid phosphatase-positive multinucleated cells [TRAP (+)
MNC] induced by l, 25 (OH) 2 D 3, PTH (l–34) or Interleukin-1α (IL-1α). The minimum …
bone culture. To test the effect of IL-4 on the formation of osteoclast-like cells, we used a
mouse bone marrow culture system that formed mononuclear and multinucleated cells with
osteoclast characteristics. Recombinant mouse IL-4 dose-dependently inhibited the
formation of tartrate-resistant acid phosphatase-positive multinucleated cells [TRAP (+)
MNC] induced by l, 25 (OH) 2 D 3, PTH (l–34) or Interleukin-1α (IL-1α). The minimum …