Osteogenesis in transplants of bone marrow cells

AJ Friedenstein, II Piatetzky-Shapiro… - …, 1966 - journals.biologists.com
AJ Friedenstein, II Piatetzky-Shapiro, KV Petrakova
Development, 1966journals.biologists.com
After heterotopic (eg subcutaneous) transplantation of bone marrow, haemopoiesis in the
graft ceases; reticular tissue develops instead, and later bone is formed. The result can be
achieved by grafting either free pieces of bone marrow or those placed in diffusion
chambers (;). In the case of free transplantation the bone formed is later filled with bone
marrow. After transplantation in diffusion chambers haemopoiesis does not recur despite the
development of a considerable mass of bone in the chambers.
Abstract
After heterotopic (e.g. subcutaneous) transplantation of bone marrow, haemopoiesis in the graft ceases; reticular tissue develops instead, and later bone is formed . The result can be achieved by grafting either free pieces of bone marrow or those placed in diffusion chambers (; ). In the case of free transplantation the bone formed is later filled with bone marrow. After transplantation in diffusion chambers haemopoiesis does not recur despite the development of a considerable mass of bone in the chambers .
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