[HTML][HTML] Activation of p38 mitogen-activated protein kinase by lipopolysaccharide in human neutrophils requires nitric oxide-dependent cGMP accumulation

DD Browning, ND Windes, DY Richard - Journal of Biological Chemistry, 1999 - ASBMB
This study examined the signal transduction pathway (s) leading to phosphorylation of p38
in human neutrophils stimulated with lipopolysaccharide and formyl peptides. Blockade of
the nitric oxide (NO) pathway in neutrophils with the NO synthase inhibitorN-nitro-l-arginine
methyl ester or by treatment with the NO scavenger 2-phenyl-tetramethylimidazoline-1-oxyl-
3-oxide attenuated phosphorylation of the mitogen-activated protein kinase p38 in response
to lipopolysaccharide but not fMet-Leu-Phe. Using the NO releasing agentsS-nitroso-N …