[HTML][HTML] Differential activation of mitogen-activated protein kinases by nitric oxide-related species
HM Lander, AT Jacovina, RJ Davis… - Journal of Biological …, 1996 - ASBMB
Many studies have identified nitric oxide (NO) and related chemical species (NO x) as
having critical roles in neurotransmission, vasoregulation, and cellular signaling. Previous
work in this laboratory has focused on elucidating the mechanism of NO x signaling in cells.
We have demonstrated that NO x-induced activation of the guanine nucleotide-binding
protein p21 ras leads to nuclear translocation of the transcription factor NFκB. Here, we
investigated whether intermediary signaling elements, namely the mitogen-activated protein …
having critical roles in neurotransmission, vasoregulation, and cellular signaling. Previous
work in this laboratory has focused on elucidating the mechanism of NO x signaling in cells.
We have demonstrated that NO x-induced activation of the guanine nucleotide-binding
protein p21 ras leads to nuclear translocation of the transcription factor NFκB. Here, we
investigated whether intermediary signaling elements, namely the mitogen-activated protein …