Leukocyte infiltration into inflammatory or injured tissues requires a variety of cell-associated
and soluble factors that mediate the communications between circulating leukocytes and
vascular cells. During the past decade, a superfamily of polypeptide leukocyte
chemoattractants known as chemokines has been identified and demonstrated to selectively
induce rapid endothelial cell adhesion and transmigration of leukocyte subpopulations.
Chemokines are produced by virtually every mammalian somatic cell type in response to …