Vascular development and disorders: molecular analysis and pathogenic insights
P Carmeliet, D Collen - Kidney international, 1998 - kidney-international.org
Distinct cellular processes mediate blood vessel formation during embryogenesis [1–6].
Initially, mesodermal cells differentiate in situ into early hemangioblasts and form cellular
aggregates (blood islands), in which the inner cell population develops into hematopoietic
precursors and the outer cell population gives rise to the primitive endothelial cells. In vitro
findings suggest that basic fibroblast growth factor (bFGF or FGF2) may participate in
angioblast differentiation via induction of a cellular receptor for vascular endothelial growth …
Initially, mesodermal cells differentiate in situ into early hemangioblasts and form cellular
aggregates (blood islands), in which the inner cell population develops into hematopoietic
precursors and the outer cell population gives rise to the primitive endothelial cells. In vitro
findings suggest that basic fibroblast growth factor (bFGF or FGF2) may participate in
angioblast differentiation via induction of a cellular receptor for vascular endothelial growth …