Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog
I Damon, PM Murphy, B Moss - Proceedings of the National …, 1998 - National Acad Sciences
I Damon, PM Murphy, B Moss
Proceedings of the National Academy of Sciences, 1998•National Acad SciencesA secreted CC chemokine homolog, encoded by the MC148 gene of molluscum
contagiosum virus, potently interfered with the chemotaxis of human monocytes,
lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines
with diverse receptor specificities. Evidence that the viral protein binds to human chemokine
receptors was obtained by competition binding and calcium mobilization experiments. The
broad spectrum chemokine antagonistic activity of MC148 can explain the prolonged …
contagiosum virus, potently interfered with the chemotaxis of human monocytes,
lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines
with diverse receptor specificities. Evidence that the viral protein binds to human chemokine
receptors was obtained by competition binding and calcium mobilization experiments. The
broad spectrum chemokine antagonistic activity of MC148 can explain the prolonged …
A secreted CC chemokine homolog, encoded by the MC148 gene of molluscum contagiosum virus, potently interfered with the chemotaxis of human monocytes, lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines with diverse receptor specificities. Evidence that the viral protein binds to human chemokine receptors was obtained by competition binding and calcium mobilization experiments. The broad spectrum chemokine antagonistic activity of MC148 can explain the prolonged absence of an inflammatory response in skin tumors that harbor replicating molluscum contagiosum virus.
National Acad Sciences
