A double blind placebo controlled crossover study of prostacyclin in man
GA FitzGerald, LA Friedman, I Miyamori, J o'Grady… - Life sciences, 1979 - Elsevier
GA FitzGerald, LA Friedman, I Miyamori, J o'Grady, PJ Lewis
Life sciences, 1979•ElsevierProstacyclin sodium (PGI 2) was administered in a double blind crossover trial to 6 normal
males at infusion rates of 2, 4 and 8 ng/kg/minute. Substantial (p< 0.001) shifts of the log
dose response curve of ADP induced platelet aggregation occured during the highest
infusion rate of PGI 2. This was associated with a small but significant fall in diastolic blood
pressure (− 6.3±1.6 mm Hg, p< 0.01) and a rise in heart rate (+ 25.5±6.5 beats/minute, p<
0.001). Plasma renin activity rose in a dose related manner with PGI 2 but plasma …
males at infusion rates of 2, 4 and 8 ng/kg/minute. Substantial (p< 0.001) shifts of the log
dose response curve of ADP induced platelet aggregation occured during the highest
infusion rate of PGI 2. This was associated with a small but significant fall in diastolic blood
pressure (− 6.3±1.6 mm Hg, p< 0.01) and a rise in heart rate (+ 25.5±6.5 beats/minute, p<
0.001). Plasma renin activity rose in a dose related manner with PGI 2 but plasma …
Abstract
Prostacyclin sodium (PGI2) was administered in a double blind crossover trial to 6 normal males at infusion rates of 2, 4 and 8 ng/kg/minute. Substantial (p < 0.001) shifts of the log dose response curve of ADP induced platelet aggregation occured during the highest infusion rate of PGI2. This was associated with a small but significant fall in diastolic blood pressure (−6.3± 1.6 mm Hg, p < 0.01) and a rise in heart rate (+25.5 ± 6.5 beats/minute, p < 0.001). Plasma renin activity rose in a dose related manner with PGI2 but plasma aldosterone and plasma norepinephrine did not change. Marked facial flushing occured with PGI2.
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