[HTML][HTML] Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and− 2
WL Smith, RM Garavito, DL DeWitt - Journal of Biological Chemistry, 1996 - ASBMB
Prostaglandin endoperoxide H synthases (PGHSs) 1 catalyze the conversion of arachidonic
acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1)(1). Before 1991,
only one PGHS had been described, the isozyme now called PGHS-1, COX-1 (for
cyclooxygenase-1) or the constitutive enzyme. At that time Simmons and Herschman and
their colleagues discovered mRNAs whose expression was induced in chicken and mouse
fibroblasts in response to src and tumor-promoting phorbol esters, respectively, and which …
acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1)(1). Before 1991,
only one PGHS had been described, the isozyme now called PGHS-1, COX-1 (for
cyclooxygenase-1) or the constitutive enzyme. At that time Simmons and Herschman and
their colleagues discovered mRNAs whose expression was induced in chicken and mouse
fibroblasts in response to src and tumor-promoting phorbol esters, respectively, and which …