The effects of intravenous endotoxin on various host-effector molecules
TB Casale, ZK Ballas, MA Kaliner… - Journal of allergy and …, 1990 - Elsevier
To understand better the pathogenesis of gram-negative infections, we administered a
single intravenous injection of Escherichia coli RE-2 endotoxin (4 ng/kg) to five normal
volunteers and periodically measured various host-effector molecules in blood. All subjects
had a significant (p< 0.05) increase in temperature (maximum of 1.3±0.1° C at 4 hours) and
white blood cell count (maximum of 7700±1800 cells per cubic millimeters at 8 hours).
Thymocyte costimulatory activity in blood was markedly increased 2 hours after endotoxin …
single intravenous injection of Escherichia coli RE-2 endotoxin (4 ng/kg) to five normal
volunteers and periodically measured various host-effector molecules in blood. All subjects
had a significant (p< 0.05) increase in temperature (maximum of 1.3±0.1° C at 4 hours) and
white blood cell count (maximum of 7700±1800 cells per cubic millimeters at 8 hours).
Thymocyte costimulatory activity in blood was markedly increased 2 hours after endotoxin …