Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis
MK Shaw, JB Lorens, A Dhawan, R DalCanto… - The Journal of …, 1997 - rupress.org
MK Shaw, JB Lorens, A Dhawan, R DalCanto, HY Tse, AB Tran, C Bonpane, SL Eswaran…
The Journal of experimental medicine, 1997•rupress.orgExperimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease
of the central nervous system which serves as a model for the human disease multiple
sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral
gene, construct to express interleukin 4, and can delay the onset and reduce the severity of
EAE when adoptively transferred to myelin basic protein–immunized mice. Thus, T
lymphocytes transduced with retroviral vectors can deliver “regulatory cytokines” in a site …
of the central nervous system which serves as a model for the human disease multiple
sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral
gene, construct to express interleukin 4, and can delay the onset and reduce the severity of
EAE when adoptively transferred to myelin basic protein–immunized mice. Thus, T
lymphocytes transduced with retroviral vectors can deliver “regulatory cytokines” in a site …
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein–immunized mice. Thus, T lymphocytes transduced with retroviral vectors can deliver “regulatory cytokines” in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.
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