Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein
BL McRae, MK Kennedy, LJ Tan, MC Dal Canto… - Journal of …, 1992 - Elsevier
Proteolipid protein (PLP) is a major component of the central nervous system (CNS) myelin
membrane and has been shown to induce acute experimental autoimmune
encephalomyelitis (EAE) in genetically susceptible animals. Here we describe conditions by
which a relapsing-remitting form of EAE can be reliably induced by SJL/J mice either actively
immunized with the major encephalitogenic PLP peptide, PLP 139–151 (S), or following
adoptive transfer of PLP 139–151 (S)-specific T cells. The disease follows a reliable …
membrane and has been shown to induce acute experimental autoimmune
encephalomyelitis (EAE) in genetically susceptible animals. Here we describe conditions by
which a relapsing-remitting form of EAE can be reliably induced by SJL/J mice either actively
immunized with the major encephalitogenic PLP peptide, PLP 139–151 (S), or following
adoptive transfer of PLP 139–151 (S)-specific T cells. The disease follows a reliable …