Myelin proteolipid protein induces demyelinating disease in mice
JL Trotter, HB Clark, KG Collins… - Journal of the …, 1987 - Elsevier
Using two methods of immunization (A and B), 5 10 (A) and 27 45 (B), BALB/c by J mice
immunized with human myelin proteolipid protein developed a demyelinating disease with a
spectrum of chronic progressive to relapsing-remitting courses. Demyelinative lesions were
seen histopathologically in all clinically affected animals that were examined. Many of the
clinically unaffected animals also had histopathologic evidence of demyelination. Some of
the animals had evidence of multiple ages of foci of activity. Evidence is presented that …
immunized with human myelin proteolipid protein developed a demyelinating disease with a
spectrum of chronic progressive to relapsing-remitting courses. Demyelinative lesions were
seen histopathologically in all clinically affected animals that were examined. Many of the
clinically unaffected animals also had histopathologic evidence of demyelination. Some of
the animals had evidence of multiple ages of foci of activity. Evidence is presented that …