[HTML][HTML] Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase (∗)
J Wang, KR Auger, L Jarvis, Y Shi… - Journal of Biological …, 1995 - ASBMB
Phosphatidylinositol 3-kinase (PI 3-kinase) has been shown to play a key role in growth
factor signaling pathways, although its signaling mechanism has not been fully elucidated.
Using the yeast interaction trap system, we have identified Grb2 as a PI 3-kinase interacting
protein. Our experiments demonstrate that p85, the regulatory subunit of PI 3-kinase,
interacts with Grb2 in vivo, and this interaction is independent of growth factor stimulation.
The direct association between Grb2 and p85 was reconstituted in vitro with glutathione S …
factor signaling pathways, although its signaling mechanism has not been fully elucidated.
Using the yeast interaction trap system, we have identified Grb2 as a PI 3-kinase interacting
protein. Our experiments demonstrate that p85, the regulatory subunit of PI 3-kinase,
interacts with Grb2 in vivo, and this interaction is independent of growth factor stimulation.
The direct association between Grb2 and p85 was reconstituted in vitro with glutathione S …