Delayed graft function, acute rejection, and outcome after cadaver renal transplantation: a multivariate analysis

C Troppmann, KJ Gillingham, E Benedetti… - …, 1995 - journals.lww.com
C Troppmann, KJ Gillingham, E Benedetti, PS Almond, RWG Gruessner, JS Najarian…
Transplantation, 1995journals.lww.com
The impact of delayed graft function on outcome after cadaver renal transplantation has
been controversial, but most authors fail to control their analyses for the presence or
absence of rejection. We studied 457 adult recipients of primary cadaver allografts at a
single institution during the cyclosporine era. All patients received sequential
immunosuppression. The incidence of delayed graft function (defined as dialysis being
required during the first week after transplant) was 23%. There was a significant association …
Abstract
The impact of delayed graft function on outcome after cadaver renal transplantation has been controversial, but most authors fail to control their analyses for the presence or absence of rejection. We studied 457 adult recipients of primary cadaver allografts at a single institution during the cyclosporine era. All patients received sequential immunosuppression. The incidence of delayed graft function (defined as dialysis being required during the first week after transplant) was 23%. There was a significant association between delayed graft function and cold ischemia time> 24 hr (P= 0.0001) and between delayed graft function and the occurrence of at least one biopsy-proven rejection episode (P= 0.004).
Lippincott Williams & Wilkins