[HTML][HTML] The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to …
SK Moestrup, R Kozyraki, M Kristiansen… - Journal of Biological …, 1998 - ASBMB
The present report shows the molecular characterization of the rat 460-kDa epithelial
glycoprotein that functions as the receptor facilitating uptake of intrinsic factor-vitamin B 12
complexes in the intestine and kidney. The same receptor represents also the yolk sac target
for teratogenic antibodies causing fetal malformations in rats. Determination of its primary
structure by cDNA cloning identified a novel type of peripheral membrane receptor
characterized by a cluster of eight epidermal growth factor type domains followed by a …
glycoprotein that functions as the receptor facilitating uptake of intrinsic factor-vitamin B 12
complexes in the intestine and kidney. The same receptor represents also the yolk sac target
for teratogenic antibodies causing fetal malformations in rats. Determination of its primary
structure by cDNA cloning identified a novel type of peripheral membrane receptor
characterized by a cluster of eight epidermal growth factor type domains followed by a …